The MedChem Project and BioByte Corp. in Claremont, CA, maintains the MedChem database. This database contains more than 55,000 compounds with 75,000 names and 32,000 CAS numbers. In addition, there are 61,000 measured logP values, 13,900 pKa values, 26,000 activities, and Rubicon 3D coordinates for almost 49,000 structures.
The Medchem database is available in Daylight's TDT format for THOR/Merlin users.
The Medchem database is licensed on an annual basis. Periodic updates are included with the subscription.