| Date | Language | and... | Toolkits (4.5x) | Applications (4.5x) |
|---|---|---|---|---|
| 1983 | SMILES | Simplified Molecular Input Line Entry System introduced (at EPA by David Weininger) | SMILES, etc. | All! |
| 1984 | SMILES | Canonicalization algorithm makes Thor possible. | SMILES, Thor, etc. | Thor, Merlin |
| 1986 1995 |
SMARTS | SMILES ARbitrary TargetS introduced, subgraph pattern language, superset of SMILES | SMARTS, Merlin | Merlin |
| 1986 | TD T | Thor Data Trees introduced | Thor | Thor |
| 1987 | Fingerprints | Fingerprints and their ASCII encoding makes Merlin possible. | Fingerprint, Merlin | Merlin, MCL |
| 1989 | Isomeric SMILES | Stereoisomeric and isotopic SMILES introduced. | SMILES, etc. | Thor, Merlin , etc. |
| 1990 | C port (4.1) allows arbitrary length SMILES (>512) | |||
| 1990 | Daylight Toolkit API - Stable toolkit function libraries. | |||
| 1993 |
Chuckles Chortles Charts Monomer SMILES (MDEF) |
Combinatorial chemistry tools introduced. | SMILES, Monomer | Thor, Merlin |
| 1994 | MCL | Merlin Control Language | Merlin | MCL |
| 1995 | CEX | Free CEX tools from CEX consortium. | ||
| 1996 | Reaction SMILES | Reaction SMILES introduced | SMILES, Reaction | Thor, Merlin |
| 1996 | DayPerl | DayPerl contributed by Alex Wong and Chiron. | ||
| 1996 | HTML/CGI | DayHTML and DayCGI tools introduced. | DayCGI | Thor, Merlin, custom apps |
| 1998 | Daylight Java Tools introduced. | |||
Daylight Chemical Information Systems Inc.