Three Component Library

• Thiazoline-2-Imines
  (Watson et al. Random and Rational, Geneva 1996)
  
  • R1: 12 isothiocyanates
  • R2: 99 amines
  • R3: 59 haloketones

• Fully enumerated library = 12 × 99 × 59 = 70092 compounds

• Select 8 × 40 × 20 = 6400 compounds

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