An opportunity has arisen to work with John Wiley & Sons on a substructure searchable database of enzyme inhibitors from the book "The Handbook of Enzyme Inhibitors" written by Helmward Zollner. In GlaxoWellcome we have built a prototype database, from the inhibition constants data, for enzymes which also exist in the Brookhaven Protein Database. Zollner's book does not contain any structures so small molecule chemical structures were added from other sources.

The database name is "inhibitors" and contains Merlin searchable fields for:

• Inhibitor name
• Enzyme name
• Type (i.e. competitive vs. non-competitive)
• Percent Inhibition
• E.C. Number
• Brookhaven code(s)

To take this forward and produce a maintainable database, Daylight CIS and Wiley & Sons need to know if there is sufficient interest for a commercial product.

If you feel you, or your company would be interested please contact Daylight CIS.

The database is available during MUG '97, please feel free to try it. Try looking up GLUCOSE as a name in xvthor as a typical page. Remember it is a prototype and its commercial development will depend on sufficient interest.

John's HTML Presentation