World Drug Index

With all the powerful tools becoming available to manipulate chemical structures and the data associated with them, there is a growing need for good quality to data for these tools to work on. The World Drug Index, produced by Derwent Information and formatted and distributed by Daylight, amongst others, is one such database. This presentation will look at the content and source of the data in WDI, to hopefully show how it is such a valuable source of information for those involved in developing and marketing new drugs.

World Drug Index - Coverage

Contains:

• Data on all marketed drugs worldwide
• Information on development drugs worldwide
  • Including Trial Preparations
• Approx. 54,000 drugs to date
• About 5,700 manufacturers
• Coverage from 1964

World Drug Index - Sources

• Literature articles from over 1,200 journals
• Conference proceedings (20 covered in 1996; at least 20 being covered in 1997)
• 14 Pharmacopoeias
• USAN, INN and other Approved Name lists

World Drug Index - Journals

• Journals covered by Derwent Drug File
• Wide International coverage of countries and publishers, for example:
  • Brazil, Canada, China, France, Germany, India, Japan, Korea, Netherlands, Norway, Switzerland, UK, USA ...
  • ACS, BMA, Chapman & Hall, Elsevier, RSC, Springer Verlag..
• List of journals covered is reviewed periodically with users
  • Additions and/or deletions can be made as the value of journals in a particular area can change over a period of time

World Drug Index - Conferences

A good variety of conferences will be covered in 1997, from a wide range of countries, including:

• Jan - 2nd Winter Conf. on Medicinal and Bioorganic Chemistry, Steamboat Springs, USA
• Mar - 98th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, San Diego
• Mar - 70th Annual Meeting of the Japanese Pharmacological Society, Chiba, Japan
• April/Sept - ACS National Meetings,
• May - 11th Noordwijkerhout-Camerino Symposium - Trends in Drug Research, Netherlands
• June - XVIth Congress of the International Society on Thrombosis and Haemostasis, Florence, Italy
• June - 20th Intl Congress of Chemotherapy, Sydney, Australia
• July - AFMC International Medicinal Chemistry Symposium AIMECS '97, Seoul, Korea
• Sept - 9th RSC-SCI Medicinal Chemistry Symposium, Cambridge, UK
• Sept - 1st Italian-Swiss Meeting on Med. Chemistry, Turin, Italy
• Sept - 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada
• Nov - 70th Scientific Sessions of the American Heart Association, Orlando, USA
• Nov - 3rd World Congress on Inflammation, Tokyo, Japan
• Nov - Xth EULAR Symposium on New Antiinflammatory & Immunomodulating Agents, Vienna, Austria

Full List of Conferences

World Drug Index - Search Fields

The searchable fields include

• Structures
• Pharmacological Activities
• Mechanism of Action
• Treatment and Adverse Effects
• Interactions and Contraindications

World Drug Index - Some Features

• Pharmacological Activity keywords
  • Structure - Activity correlations
• Mechanism Of Action field
  • Being progressively cleaned up to remove un-necessary or incorrect terms
  • Keywords used instead of unrestricted text, to improve ease of search
• Adverse effects etc.
  • Structure -"adverse" activity correlations ("one mans meat is another man's poison..." c.f. warfarin etc.)
  • What drugs have been withdrawn due to specified side effects? (e.g. side effects = death!)
• Synonyms & Trade Names
  • WDI contains very many names, synonyms and trade names from a number of sources, including several approved name lists, which enables questions to be asked such as:
    What is White-Willow-Bark?
• Manufacturers & Country
  • Alongside the Trade Names, details are given of the Manufacturers and the countries in which the Trade Names apply. It is therefore possible to ask questions like:
    What trade names are used for paracetamol in Japan?
• Combination Preps. included
• Source References included since 1996
• Jarvis Patrick clustering added by Daylight

World Drug Index - Lite

• From Daylight Only
• Contains:
  • All chemical structural information
  • All name, synonym, trade name information
  • Pharmacological activity keywords
• Does not contain:
  • Mechanism of action
  • Treatment, (Contra)indications, Precautions
  • Interactions, Adverse Effects

World Drug Index - Lite

• Priced - less than full version
• For Small to Medium Sized companies
• For departments that do not need full version

World Drug Index - HTML versions

• INTRANET versions of WDI & WDI-Lite
• Simple search queries
  • Text (Names etc.)
  • CAS RN
  • SMILES
• Demonstration available on Internet
  • Sub-set of WDI
  • Name, CAS RN, SMILES lookup in demonstration
  • Structure editor (GRINS)
• Access via Daylight home-page
  • URL http://www.daylight.com/daycgi/wdi

World Drug Index - HTML version

Example searched in the WDI95 demo database showing several data fields and the simplified interface: terfenadine

World Drug Index - HTML versions

• New Pricing mechanism
  • Departmental Use (Small/Departmental group - Single site)
  • National Use (Multi site/Multi Department - Single country)
  • Global use (Unlimited usage worldwide)

For more information on the Derwent World Drug Index, contact:

Gez Cross

Derwent Information

gcross@derwent.co.uk