Basic Concepts

• What do we mean by molecular diversity?

• Structural Diversity Property Diversity

• • templates / scaffolds / backbones • lipophilicity

• • functional groups / fragments • acid/base

• • bridges / bioisosteres • H-bonding

• • aromatic / aliphatic • dipolarity

• • geometry (shape, chirality, • charge

• connectivity, spatial disposition) • size

Notes: