Baldwin’s Rules for Ring Closure

In the 1970s, J.E. Baldwin described a set of rules for the ease of ring closure in 3-7 membered rings. These rules covered Exo- and Endo- closure at sp3, sp2 and sp atoms.

The corresponding favorable ring opening transformations may be specified as reactions in the Daylight reaction toolkit.

[H:1][O:2][C;r5,r6:3]([:4])[;O,N:5][*:6]>>