RECAP -

Retrosynthetic Combinatorial Analysis Procedure:

A Powerful New Technique for Identifying Privileged Molecular Fragments.

Xiao Qing Lewell , Duncan Judd, Steve Watson, Mike Hann

GlaxoWellcome, Stevenage, UK. E-mail: xql4406@ggr.co.uk

Abstract

Presentation slides:

Introduction

Successful Modern Pharmaceutical Company

Combinatorial Library Construction

Motif-based Library Design

Contrasting Techniques for Identifying Motifs

RECAP Illustration

Bond Cleavage Rules

An Example of Cleavage

RECAP Technical Details

Applications

Fragmenting WDI Molecules

Relate Fragment to Therapeutic Activity

Library Monomer Design

Appropriate Monomer Mass

Indole as Potential Monomer for Amide Chemistry

Design or Select Monomer

WDI Fragment Knowledge Base

Summary

Acknowledgement