NOTE: ***************************************************
NOTE: * World Drug Index 2001 Version 2 *
NOTE: * COPYRIGHT [C] 2001 DERWENT INFORMATION LTD. *
NOTE: ***************************************************
Opened "/choya/thordb/wdi012.THOR@origin.daylight.com:thor" with permission "r".
| SMILES |
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Derwent external registry name EPITESTOS
Isomer 
Substructure keywords ANDROSTANE; KETONE,CYCLIC; ALCOHOL; OLEFIN
Derwent preferred name EPITESTOSTERONE
Activity keywords ANDROGENS
Derwent name EPITESTOS
Ave molecular weight 288.428
2D-coordinates 42 numerical data Comment ~
Derwent Molform C19 H28 O2
CAS number 481-30-1
Name EPITESTOSTERONE
Mechanism of action ANDROGEN
Derwent update code 1990.1-1998.4
Derwent external registry name TESTOSTER
Isomer 
Derwent preferred name TESTOSTERONE
Activity keywords ANDROGENS
Derwent name TESTOSTER
International non-proprietary name TESTOSTERONE INN/status Rec.
Ave molecular weight 288.428
Adverse effects BILIARY-TRACT-DISEASE: cholestatic-icterus; ELECTROLYTE-METAB.DISORDER; INFERTILITY: oligospermia; MENTAL-DISORDER: anxiety; GASTROENTEROPATHY: GI-bleeding; MENTAL-DISORDER: depression; MISC: alopecia; MISC: edema; MISC: excessive sexual-stimulation; MISC: endocrine-disease; MISC: virilization.; MISC: sexual-disorder; MISC: premature epiphyseal-closure (in prepubertal male); MISC: precocious sexual-development; MISC: nausea; MISC: libido-changes; MISC: infertility; MISC: hirsutism; SKIN-DISEASE: seborrhea; SKIN-DISEASE: acne; PROSTATE-DISEASE: prostate-changes; PERIPHERAL-NERVE-DISEASE: paresthesia; PENIS-DISEASE: priapism; PENIS-DISEASE: phallic-enlargement (in prepubertal male); PENIS-DISEASE: increased erection-frequency; OSTEOPATHY; MISC: headache; MISC: decreased ejaculatory-volume; MENTAL-DISORDER: neurosis
Precautions and warnings Epilepsy; history of epilepsy; hepatopathy; withdraw in the event of hypercalciuria; withdraw in the event of hypercalcemia; withdraw at first signs of virilization; skeletal-metastases; nephropathy; monitor PSA levels prior to and during therapy; migraine; hypertension; hypernephroma; history of migraine; bronchial carcinoma; children under 15 yr.; diabetes-mellitus; heart-failure; elderly; examine for prostatic changes
Interactions Anticoagulants; hepatic-enzyme-inducing drugs; oxyphenbutazone.
Contraindications Hypercalcemia; male breast-carcinoma; prostatic-carcinoma; women.; untreated heart-failure; nephrotic-syndrome; ischemic cardiopathy; hypercalciuria
Mechanism of action ANDROGEN; FSH-antagonist.; ICSH-antagonist; the steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action; high-dose: spermatogenesis-inhibitor; exogenous administration inhibits endogenous release via feedback inhibition of pituitary ICSH; activity in many tissues appears to depend on reduction to dihydrotestosterone which binds to cytosolic-receptor-proteins; GONADOTROPIN-ANTAGONIST
Derwent update code 1990.1-2001.1
Substructure keywords ALCOHOL; OLEFIN; ANDROSTANE; KETONE,CYCLIC
2D-coordinates 42 numerical data Comment ~
Combination Prep HOMOSTEN Manufacturer LEPETIT Country IT Components ( + chorionic-gonadotrophin )
CAS number 58-22-0
Derwent Molform C19 H28 O2
United States Adopted Name TESTOSTERONE Code USAN
Name ANDRO-100
Name ANDROGEN
Name ANDROID-T
Name ANDROLAN
Name ANDRONAQ
Name ANDROSUL
Name ANDROTEST
Name AQUA-TESTERONE
Name AQUAVIRON
Name CRISTAVIRON
Name DEP-ANDROLE
Name ENARMON
Name FRAMVIRON
Name HARVOGEN
Name HOMOSTERON
Name MALERONE
Name MALOTRONE
Name MERTESTATE
Name NARGA-HORMO-M
Name NEOTESTIS
Name ORETON-F
Name ORQUISTERON
Name PAN-TEST
Name PERANDREN
Name PRIMONIAT-T
Name PRIMOTEST-T
Name PRIMOTESTON-T
Name PROVIRON-T
Name REKTANDRON
Name STERANDRYL
Name STRONG-LAR
Name SYNANDRETS
Name SYNANDROL-F
Name SYNANDRULIN
Name TES-HOL
Name TESLEN
Name TESTAHOMEN-T
Name TESTANDRONE
Name TESTEPLEX
Name TESTIKELHORMON
Name TESTOBAN
Name TESTOBASE
Name TESTOPROPON
Name TESTORONA-TROPFEN
Name TESTOSIR
Name TESTOSTEROID
Name TESTOVENA
Name TESTRAQ
Name TESTRYL
Name VIREX
Name VIRORMONE
Name VIROSTERONE
Name VIROTEST-MARIATHERMA
Indications and usage MISC-REPRO: male-hypogonadism; MISC: endocrine-disorder; MISC: replacement-therapy in male androgen-deficiency; OSTEOPATHY: osteoporosis due to androgen-deficiency
Approved name TESTOSTERONE Code DCF
Approved name TESTOSTERONE Code DCIT
Trade name ANDRO Manufacturer FOREST Country US
Trade name ANDROGEL Manufacturer BESINS-ISCOVESCO Country FR
Trade name ANDROGEL Manufacturer UNIMED Country US
Trade name ANDROLAN Manufacturer LANNETT Country US
Trade name ANDROLAN-AQUEOUS Manufacturer LANNETT Country US
Trade name ANDROLIN Manufacturer LINCOLN Country US
Trade name ANDRONAG Manufacturer CENTRAL Country US
Trade name ANDROSORB Manufacturer NOVAVAX Country US
Trade name ANDROXON Manufacturer ORGANON Country NO
Trade name DEPOTEST Manufacturer HYREX Country US
Trade name DURA-TESTRONE Manufacturer PHARMEX Country US
Trade name HISTERONE Manufacturer HAUCK-ROSWELL Country US
Trade name HOMOGENE-S Manufacturer SPANNER Country US
Trade name HYDROTEST Manufacturer AYERST Country ?
Trade name LAR Manufacturer SEISHINDO Country JP
Trade name LONTANYL Manufacturer ROUSSEL Country FR
Trade name MALESTRONE Manufacturer KIRK Country US
Trade name MALOGEN Manufacturer STICKLEY Country CA
Trade name NENDRON Manufacturer NOYES Country US
Trade name NEO-HOMBREOL-F Manufacturer ORGANON Country ?
Trade name ORETON Manufacturer SCHERING Country VE
Trade name ORETON Manufacturer SCHERING-ESSEX Country ?
Trade name PANTESTONE Manufacturer ORGANON Country FR
Trade name PERCUTACRINE-ANDROGENIQUE-FORTE Manufacturer BESINS-ISCOVESCO Country FR
Trade name PRIMOTESTON Manufacturer SCHERING Country ET,GH,KE,LR,MU,NG,SC,TZ,UG,ZM
Trade name STEROTATE Manufacturer ULMER Country US
Trade name TESAMONE Manufacturer DUNHALL Country US
Trade name TESONE Manufacturer SIG Country US
Trade name TEST-100 Manufacturer SCHLICKSUP Country US
Trade name TESTADENOS Manufacturer FERNDALE Country US
Trade name TESTALONG Manufacturer BLAINE Country US
Trade name TESTAQUA Manufacturer KAY Country US
Trade name TESTISAN Manufacturer I.E.KIMYA Country TR
Trade name TESTODERM Manufacturer FERRING Country US
Trade name TESTOJECT Manufacturer MAYRAND Country US
Trade name TESTOLENT Manufacturer BIOFARM Country RO
Trade name TESTOLIN Manufacturer PASADENA Country US
Trade name TESTOPEL Manufacturer BARTOR Country US
Trade name TESTORAL Manufacturer ORGANON Country GB,IE,ZA
Trade name TESTOSTERON Manufacturer BERCO Country DE
Trade name TESTOSTERONE Manufacturer BOOTS Country US
Trade name TESTOSTERONE Manufacturer GLAXO Country AU
Trade name TESTOSTERONE Manufacturer GOLDLINE Country US
Trade name TESTOSTERONE Manufacturer LEGERE Country US
Trade name TESTOSTERONE Manufacturer MILLGOOD Country US
Trade name TESTOSTERONE Manufacturer ORGANON Country AU,GB,NZ,ZA
Trade name TESTOSTERONE Manufacturer PADDOCK Country US
Trade name TESTOSTERONE Manufacturer PUREPAC Country US
Trade name TESTOSTERONE Manufacturer QUAD-PHARMACEUTICALS Country US
Trade name TESTOSTERONE Manufacturer RUGBY Country US
Trade name TESTOSTERONE Manufacturer TOWNE-PAULSEN Country US
Trade name TESTOSTERONE-IMPLANTS Manufacturer ORGANON Country ZA
Trade name TESTOSTERONE-NF Manufacturer UNIT.RES. Country US
Trade name TESTOVIRON-T Manufacturer SCHERING Country DE
Trade name TESTRO-MED Manufacturer MEDICS Country US
Trade name TESTRONE Manufacturer SMITH-MILLER+PATCH Country US
Trade name TOSTREX Manufacturer CELLEGY Country ?
Trade name TRIOLANDREN Manufacturer CIBA Country NO
CAS Number 481-30-1
CAS Number 58-22-0
Name ANDRO100
Name ANDRO
Name ANDROGEL
Name ANDROGEN
Name ANDROIDT
Name ANDROLAN
Name ANDROLANAQUEOUS
Name ANDROLIN
Name ANDRONAG
Name ANDRONAQ
Name ANDROSORB
Name ANDROSUL
Name ANDROTEST
Name ANDROXON
Name AQUATESTERONE
Name AQUAVIRON
Name CRISTAVIRON
Name DEPANDROLE
Name DEPOTEST
Name DURATESTRONE
Name ENARMON
Name EPITESTOSTERONE
Name FRAMVIRON
Name HARVOGEN
Name HISTERONE
Name HOMOGENES
Name HOMOSTERON
Name HYDROTEST
Name LAR
Name LONTANYL
Name MALERONE
Name MALESTRONE
Name MALOGEN
Name MALOTRONE
Name MERTESTATE
Name NARGAHORMOM
Name NENDRON
Name NEOHOMBREOLF
Name NEOTESTIS
Name NSC9700
Name ORETON
Name ORETONF
Name ORQUISTERON
Name PANTEST
Name PANTESTONE
Name PERANDREN
Name PERCUTACRINEANDROGENIQUEFORTE
Name PRIMONIATT
Name PRIMOTESTON
Name PRIMOTESTONT
Name PRIMOTESTT
Name PROVIRONT
Name REKTANDRON
Name STERANDRYL
Name STEROTATE
Name STRONGLAR
Name SYNANDRETS
Name SYNANDROLF
Name SYNANDRULIN
Name TESAMONE
Name TESHOL
Name TESLEN
Name TESONE
Name TEST100
Name TESTADENOS
Name TESTAHOMENT
Name TESTALONG
Name TESTANDRONE
Name TESTAQUA
Name TESTEPLEX
Name TESTIKELHORMON
Name TESTISAN
Name TESTOBAN
Name TESTOBASE
Name TESTODERM
Name TESTOJECT
Name TESTOLENT
Name TESTOLIN
Name TESTOPEL
Name TESTOPROPON
Name TESTORAL
Name TESTORONATROPFEN
Name TESTOSIR
Name TESTOSTEROID
Name TESTOSTERON
Name TESTOSTERONE
Name TESTOSTERONEIMPLANTS
Name TESTOSTERONENF
Name TESTOVENA
Name TESTOVIRONT
Name TESTRAQ
Name TESTROMED
Name TESTRONE
Name TESTRYL
Name TOSTREX
Name TRIOLANDREN
Name VIREX
Name VIRORMONE
Name VIROSTERONE
Name VIROTESTMARIATHERMA
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