Hypertablet
`pKa' table(s) from database medchem98demo:
Local name: PROPRANOLOL
| pKa |
pKa/solv |
pKa/ref |
pKa/foot |
pKa/temp |
pKa/comment |
| 9.60 |
water |
Manners,C.N. & Payling,D., Fisons, Xenobiot. 19, 1387 (1989) & Private Communication (1986) |
|
|
|
| 9.60 |
|
Lullmann,H. & Wehling,M., Biochem. Pharmacol., (1979) 28, 3409 |
|
|
|
| 9.45 |
|
Wang,P.-H. & Lien,E.J., J. Pharm. Sci., (1980) 69, 662 |
|
|
|
| 9.23 |
|
Schoenwald,R.D. & Huang,H-S., J. Pharm. Sci., (1983) 72, 1266 |
|
|
|
| 9.13 |
methanol/water: 50/50 v/v |
Mauleon,D., Pujol,M. & Rosell,G., Eur.J.Med.Chem., 23, 421 (1988) |
|
25 |
|
| 9.95 |
|
Hachisu,M. & Koeda,T., J. Pharm. Dyn., (1980) 3, 183 |
|
|
|
| 9.47 |
water |
Avdeef,A., STAN, 2, 93, (1995) |
Preferred Value |
|
|
| 9.45 |
|
Levy,J.V., Europ. J. Pharmacol., (1968) 2, 250 |
|
|
|
| 9.7 |
water |
Recanatini,M., Univ. Bologna, Private Communication |
From log P/pH profile |
|
|
|